UCSF home page UCSF home page About UCSF Search UCSF UCSF Medical Center
UCSF navigation bar
UCSF home page UCSF home page About UCSF Search UCSF UCSF Medical Center

Publications

Lemieux GA, Cunningham KA, Lin L, Mayer F, Werb Z, Ashrafi K (2015) Kynurenic Acid Is a Nutritional Cue that Enables Behavioral Plasticity. Cell 160: 119-131

Lemieux GA and Ashrafi K (2014) Insights and challenges in using C. elegans for investigation of fat metabolism. Critical Reviews in Biochemistry and Molecular Biology 17:1-16 pdf

Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K and Giacomini KM (2014) OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc.Natl.Acad.Sci.USA. (PNAS) 111:9983-9988

Cunningham KA, Bouagnon AD, Barros AG, Lin L, Malard L, Romano-Silva MA and Ashrafi K (2014) Loss of a neural AMP-activated kinase mimics the effects of elevated serotonin on fat, movement, and hormonal secretions. PLoS Genetics 9: e1004394

Ward JD, Mullaney B, Schiller BJ, He le D, Petnic SE, Couillault C, Pujol N, Bernal TU, Van Gilst MR, Ashrafi K, Ewbank JJ and Yamamoto KR (2014) Defects in the C. elegans acyl-CoA synthase, acs-3, and nuclear hormone receptor, nhr-25, cause sensitivity to distinct, but overlapping stresses. PLoS One 9: e92552

Barros AG, Bridi JC, de Souza BR, de Castro Junior C, de Lima Torres KC, Malard L, Jorio A, de Miranda DM, Ashrafi K and Romano-Silva MA (2014) Dopamine signaling regulates fat content through β-oxidation in Caenorhabditis elegans. PLoS One 9: e85874

Ward JD, Bojanala N, Bernal T, Ashrafi K, Asahina M and Yamamoto KR (2013) Sumoylated NHR-25/NR5A Regulates Cell Fate during C. elegans Vulval Development. PLoS Genetics 9: e1003992

Lemieux GA, Keiser MJ, Sassano MF, Laggner C, Mayer F, Bainton RJ, Werb Z, Roth BL, Shoichet BK, Ashrafi K (2013) In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding. PLoS Biology 11: e1001712

Chen AT-Y, Guo C, Dumas KJ, Ashrafi K and Hu PJ (2013) Effects of Caenorhabditis elegans sgk-1 mutations on lifespan, stress resistance, and DAF-16/FoxO regulation. Aging Cell 12: 932-940

Cunningham KA, Hua Z, Srinivasan S, Liu J, Lee BH, Edwards RH, Ashrafi K (2012) AMP-Activated Kinase Links Serotonergic Signaling to Glutamate Release for Regulation of Feeding Behavior in C. elegans. Cell Metabolism 16: 113-121

Barros AG de A, Liu J, Lemieux GA, Mullaney BC, Ashrafi K (2012) Analyses of C. elegans fat metabolic pathways. Methods in Cell Biology 107: 383-407

Lee BH, Liu J, Wong D, Srinivasan S, Ashrafi K (2011) Hyperactive neuroendocrine secretion causes size, feeding, and metabolic defects of C. elegans Bardet-Biedl syndrome mutants. PLoS Biology 9: e1001219

Lemieux GA, Liu J, Mayer N, Bainton RJ, Ashrafi K and Werb Z (2011) A whole-organism screen identifies new regulators of fat storage. Nature Chemical Biology 7: 206-213

Lu M, Wang J, Jones KT, Ives HE, Feldman ME, Yao LJ, Shokat KM, Ashrafi K, Pearce D (2010) mTOR complex-2 activates ENaC by phosphorylating SGK1. Journal of American Society of Nephrology 21:811-818

Heo J-M, Livnat-Levanon N, Taylor EB, Jones KT, Dephoure N, Ring J, Xie J, Brodsky JL, Madeo F, Gygi SP, Ashrafi K, Glickman MH, Rutter J (2010) A stress-responsive system for mitochondrial protein degradation. Molecular Cell 40: 465-480

Mullaney BC, Blind RD, Lemieux GA, Pérez CL, Elle IC, Faergeman NJ, Van Gilst MR, Ingraham HA and Ashrafi K (2010) Regulation of C. elegans Fat Uptake and Storage by Acyl-CoA Synthase-3 Is Dependent on NR5A Family Nuclear Hormone Receptor nhr-25. Cell Metabolism 12: 398-410

Mullaney BC, Ashrafi K (2009) C. elegans fat storage and metabolic regulation. Biochimica et Biophysica Acta 1791: 474-478

Jones KT, Ashrafi K (2009) Caenorhabditis elegans as an emerging model for studying the basic biology of obesity. Disease Models Mechanisms 2: 224-229

Jones KT, Greer ER, Pearce D, Ashrafi K (2009) Rictor/TORC2 regulates Caenorhabditis elegans fat storage, body size, and development through sgk-1. PLoS Biology 3: e60

Cunningham KA, Ashrafi K (2009) Fat rationing in dauer times (Preview). Cell Metabolism 9: 113-114

Greer ER, Perez CL, Van Gilst MR, Lee BH, and Ashrafi K (2008) Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding. Cell Metabolism 8: 118-131 (2008)

Srinivasan SS, Sadegh L, Elle IC, Christensen AG, Faergeman NJ, and Ashrafi K (2008) Serotonin regulates C. elegans fat and feeding through independent molecular mechanisms. Cell Metabolism 7: 533-544

Lee B, and Ashrafi K (2008) A TRPV Channel Modulates C. elegans Neurosecretion, Larval Starvation Survival and Adult Lifespan. PLoS Genetics 4: e1000213

Husson SJ, Janssen T, Baggerman G, Bogert B, Kahn-Kirby AH, Ashrafi K, and Schoofs L (2007) Impaired processing of FLP and NLP peptides in carboxypeptidase E (EGL-21)-deficient Caenorhabditis elegans as analyzed by mass spectrometry. Journal of Neurochemistry 102: 246-60

Ashrafi K (2007) Obesity and the Regulation of Fat Metabolism (Review). WormBook (Eds, M. Chalfie and L. Girard) 9: 1-20.

Ashrafi K (2006) Mapping out starvation responses (Preview). Cell Metabolism 3: 235-236

Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J and Ruvkun G (2003) Genome-wide RNAi analysis of C. elegans fat regulatory genes. Nature 421: 267-272